Secretion for cytokinesis

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Secretion for cytokinesis

he actomyosin contractile ring involved in separating a dividing cell in two only gets so far. The job is finished, according to work from and colleagues, by a burst of secretory vesicle fusion. Doxsey's group was looking for a function for a vertebrate centrosomal protein called centriolin. A defect in cytokinesis was not what they expected to find when they knocked down centriolin function, b...

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Iqg1p links spatial and secretion landmarks to polarity and cytokinesis

Cytokinesis requires the polarization of the actin cytoskeleton, the secretion machinery, and the correct positioning of the division axis. Budding yeast cells commit to their cytokinesis plane by choosing a bud site and polarizing their growth. Iqg1p (Cyk1p) was previously implicated in cytokinesis (Epp and Chant, 1997; Lippincott and Li, 1998; Osman and Cerione, 1998), as well as in the estab...

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A time for cytokinesis

and colleagues have found that certain successful Streptococci actually avoid attachment to host cells. This contrasts with the modus operandi of most pathogenic bacteria. The M1 serotype of the highly heterogeneous Group A Streptococcus (GAS) pathogen is the most common GAS strain found in severe disease outbreaks. M1 GAS are unique in that they produce streptococcal inhibitor of complement (S...

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The UPR for cytokinesis

A stress-coping strategy of the ER is needed in every cell cycle, show Bicknell et al. (page 1017). The ER’s unfolded protein response (UPR), previously associated only with unusual or stressful conditions, is needed for the routine event of cytokinesis. The UPR is activated when the ER is overloaded with misfolded proteins. It increases ER capacity and helps reduce the load. But the authors wo...

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Bundle up for cytokinesis

In This Issue In This Issue levels of exogenously expressed PRC1 caused unusual cytoplasmic arrays of microtubules in interphase cells. Overexpressed PRC1 bundles microtubules in interphase cells. Bundle up for cytokinesis ew results from Mollinari et al. (page 1175) reveal that cytokinesis requires microtubule bundles to be formed at the spindle midzone and that the mitotic spindle–associated ...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2005

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb1712rr1